IgG4相关性疾病 IgG4 related Disease
IgG4相关前列腺炎的低功率视图。前列腺基质表现出致密的炎性浸润和纤维化（H＆E，100x）
IgG4相关疾病（IgG4-RD），以前称为IgG4相关的全身性疾病，是一种慢性炎症性疾病，其特征是组织浸润淋巴细胞和分泌IgG4的浆细胞，各种程度的纤维化（瘢痕形成）和通常迅速的反应口服类固醇。在大约51-70％的患有此疾病的人群中，血清IgG4浓度在急性期升高
它是一种复发缓解性疾病，与多个部位的肿块形成，组织破坏性病变有关，在任何部位都有特征性的组织病理学表现。如果不进行治疗，炎症和结缔组织在受影响的解剖部位的沉积可导致器官功能障碍，甚至器官衰竭。
早期发现对于避免器官损伤和潜在的严重并发症非常重要。所有有症状的IgG4-RD病例以及涉及某些解剖部位的无症状IgG4-RD都建议进行治疗 。
目录
1 症状
1.1 个体器官表现
2 组织学
2.1 下颌下腺研究
3 诊断
4 治疗
4.1 诱导缓解
4.2 保养
4.3 复发
4.4 其他干预措施
4.5 试验
5 流行病学
6 命名
7 参考
症状
已经将IgG4相关疾病描述为惰性病症。尽管可能基于观点而非客观评估，但在医学文献中，症状（如果有的话）通常被描述为轻微的。尽管存在相当大的潜在器官破坏，但这仍然存在。人们通常被描述为在诊断时一般情况良好，尽管有些人可能会有减肥史。
疼痛通常不是炎症的特征。然而，它可能作为次要效应发生，例如由于阻塞或压缩。
通常由于存在无痛肿胀或肿块，或由于肿块的并发症（例如肿块）而进行诊断。由于胰腺，胆管系统或肝脏受累引起的黄疸。症状通常归因于其他病症，并且其他诊断可能在诊断前几年进行，例如，男性的泌尿系统症状归因于共同的前列腺疾病。病变也可能偶然在放射图像上检测到，但很容易被误诊为恶性肿瘤。
报告的病例确实包括一些重要的症状或发现：
系统罕见的症状和并发症
神经性癫痫发作， 瘫痪或偏瘫，颅神经麻痹，感音神经性聋，垂体激素缺乏
视力丧失，眼球突出
心血管收缩性心包炎，心脏传导阻滞，主动脉瘤破裂， 主动脉夹层，颈动脉夹层，颅内动脉瘤，心绞痛，心源性猝死
呼吸道阻塞，胸腔积液
胃肠道食管阻塞， 肠梗阻
泌尿系肾功能衰竭，肾积水， 睾丸疼痛
个别器官表现
IgG4-RD可涉及体内的一个或多个部位。在多机构参与的情况下，所涉及的站点可能同时（同步）或在不同的不相关时段（异步）受到影响。
多年来已知的几种不同疾病现在被认为是IgG4-RD的表现。 这些包括：1型自身免疫性胰腺炎，间质性肾炎，Riedel氏甲状腺炎，Mikulicz病，Küttner肿瘤，炎性假瘤（在身体的各个部位），纵隔纤维化和一些腹膜后纤维化病例。
其他受影响的部位，在组织学上证实是IgG4-RD的表现，包括：心脏; 硬腭，食道， 胃，小肠，直肠，[ 53]肾上腺，卵巢，子宫，输尿管，膀胱， 脐尿管，和滑膜。大约1/3的病例表现出血液嗜酸性粒细胞计数增加，嗜酸粒细胞增多或嗜酸性粒细胞增多。
在确诊的IgG4-RD病例中已经报道了提示上腔静脉和精囊受累的放射学证据。
组织学
无论身体的哪个部位涉及，IgG4-RD的标志性组织病理学特征是：
致密的淋巴浆细胞（淋巴细胞和浆细胞）浸润富含IgG4阳性的浆细胞。
需要特异性地要求并进行IgG4免疫染色以检测IgG4阳性浆细胞。
纤维化，至少局部排列为storiform模式。
“Storiform”通常被称为“具有车轮图案”，但其字面意思是“编织垫[拉丁语：storea]（匆忙或稻草）”的外观。
闭塞性静脉炎。
在静脉壁和管腔内，静脉通道被致密的淋巴浆细胞浸润所消除。
与IgG4-RD相关的其他组织病理学特征是：
静脉炎没有闭塞管腔。
组织中嗜酸性粒细胞的数量增加。
颌下腺研究
在1977年的一篇文章中，对349例Küttner肿瘤（现称为“IgG4相关性唾液腺炎”）的组织学研究确定了纤维炎症过程的四个不同阶段：
第1阶段：局灶性输卵管（唾液导管周围）浸润淋巴细胞
第2阶段：淋巴细胞弥漫性浸润和严重的输卵管纤维化（唾液导管周围的瘢痕）
第3阶段：淋巴细胞明显浸润，薄壁组织萎缩（即由于收缩导致的功能区域丧失）和导管硬化（瘢痕形成导致唾液导管周围硬化）
第4阶段：实质（功能区）明显丧失和硬化（硬化） - 类似于肝硬化的过程，其中肝脏功能区域出现收缩和丧失
这可能反映了IgG4-RD中涉及的其他器官中发生的炎症过程和纤维化的发展。
诊断
诊断需要受影响器官的组织活检，并具有特征性的组织学发现。血清免疫球蛋白G4通常会升高，但情况并非总是如此。[引证需要]
治疗
治疗的目标是诱导和维持缓解，以防止受影响器官中纤维化和器官破坏的进展。
一个国际专家小组已经为IgG4-RD的管理提出了建议。 他们得出结论，在所有需要治疗的有症状的活性IgG4-RD病例中。一些无症状IgG4-RD的病例也需要治疗，因为一些器官在疾病晚期之前往往不会引起症状。建议对某些器官表现进行紧急治疗，如主动脉炎，腹膜后纤维化，近端胆管狭窄，肾小管间质性肾炎，硬脑膜炎，胰腺增大和心包炎。
诱导缓解
在未治疗的活动性疾病患者中，除非存在禁忌症，否则推荐用于诱导缓解的一线药物是糖皮质激素。糖皮质激素特征性地导致临床特征的快速且通常显著的改善，并且通常解决射线照相特征。然而，在晚期纤维化病变导致不可逆损伤的情况下，对糖皮质激素和其他当前治疗选择的反应可能很差甚至不存在。
虽然在临床试验中尚未验证，但常见的诱导方案是泼尼松龙每天30-40毫克，持续2-4周，然后逐渐减量3至6个月。然而，在糖皮质激素逐渐减量期间或之后复发是常见的。根据这些药物的当地可用性，可以考虑使用类固醇保留的免疫抑制剂，从开始治疗开始与糖皮质激素联合使用。已使用的类固醇保留剂包括利妥昔单抗，硫唑嘌呤，甲氨蝶呤和环磷酰胺，但需要进行试验以确定每种药物在IgG4-RD中的有效性。
保养
在成功诱导缓解后，可能在某些情况下给予维持治疗，例如当复发风险高或患有器官威胁表现的患者时。常见的维持治疗是泼尼松龙每天2.5-5毫克，或使用类固醇保留剂代替。
复发
复发很常见，既往复发史似乎是未来复发的有力预测指标。当在停止治疗期间发生复发并且在最初的糖皮质激素诱导后存在延长的疾病缓解时，通常可以使用糖皮质激素的再诱导策略成功地控制复发。引入类固醇保留剂也可能需要考虑复发;然而，没有一项在前瞻性对照研究中进行过测试，并且其效力超过同时使用糖皮质激素治疗所提供的证据很少。
在一项回顾性队列研究中，发现血清IgG4，IgE和血液嗜酸性粒细胞的基线浓度可独立预测利妥昔单抗治疗后有或没有糖皮质激素治疗后的复发风险。基线值越高，复发风险越大，复发时间越短。
其他干预措施
当器官受累引起局部机械问题时，可能需要进一步的器官特异性干预。例如，当肿瘤病变导致胆管阻塞时，可能需要插入胆管支架以使胆汁自由排出。
类似地，输尿管或血管支架，手术切除或放射治疗可考虑用于各种不同的呈现问题。
试验
目前正在研究用单克隆抗体（XmAb5871）评估浆母细胞定向治疗的效果和安全性，该抗体在不消耗这些免疫细胞的情况下抑制B细胞功能 。 XmAb5871以其可变结构域靶向CD19，并且具有对FcγRIIb具有增加的亲和力的Fc结构域。
流行病学
由于IgG4-RD的识别相对较新，因此对其流行病学的研究很有限。因此很难准确估计患病率。此外，几乎不可能估计发病年龄;诊断时的年龄经常被误用为发病年龄。
2011年的一项研究估计日本IgG4-RD的发病率为2.8-10.8 /百万人，中位年龄为58岁。
命名法
以前用于IgG4-RD的名称：
IgG4相关的全身性疾病（IgG4-RSD）
IgG4相关的硬化性疾病
IgG4相关的系统性硬化病
IgG4相关的自身免疫性疾病
IgG4相关的多灶性系统性纤维化
IgG4相关疾病
IgG4综合征
Hyper-IgG4疾病
系统性IgG4相关的浆细胞综合征
IgG4阳性多器官淋巴组织增生综合征
在2011年之前，IgG4-RD曾在医学文献中以各种不同的名称提及。
在2011年IgG4相关疾病国际研讨会上，IgG4相关疾病的共识名称得到了认可。 这个名称已被作为日本研究者的共识名称达成一致， 特别选择不使用“系统性”一词，因为这可能导致其他器官的恶性肿瘤被错误地诊断为另一种表现形式。 与IgG4相关的病症。
然而，国际研讨会的一些专家确实对IgG4后的疾病命名表示保留，因为其在发病机制中的作用值得怀疑，并且使用血清IgG4浓度作为生物标志物是不可靠的。
有时也使用扩展术语“免疫球蛋白G4相关疾病”。 然而，这个术语在2012年的命名建议中从未被引用，并且它的使用似乎是错误的。
另见
IgG4-related ophthalmic disease
IgG4-related prostatitis
IgG4-related skin disease
参考
Wallace, Zachary S.; Deshpande, Vikram; Mattoo, Hamid; Mahajan, Vinay S.; Kulikova, Maria; Pillai, Shiv; Stone, John H. (26 August 2015). "IgG4-Related Disease: Clinical and Laboratory Features in One Hundred Twenty-Five Patients". Arthritis & Rheumatology. 67 (9): 2466–2475. doi:10.1002/art.39205. PMC 4621270. PMID 25988916.
John H. Stone; Arezou Khosroshahi; Vikram Deshpande; John K. C. Chan; J. Godfrey Heathcote; Rob Aalberse; Atsushi Azumi; Donald B. Bloch; William R. Brugge; Mollie N. Carruthers; Wah Cheuk; Lynn Cornell; Carlos Fernandez-Del Castillo; Judith A. Ferry; David Forcione; Günter Klöppe; Daniel L. Hamilos; Terumi Kamisawa; Satomi Kasashima; Shigeyuki Kawa; Mitsuhiro Kawano; Yasufumi Masaki; Kenji Notohara; Kazuichi Okazaki; Ji Kon Ryu; Takako Saeki; Dushyant Sahani; Yasuharu Sato; Thomas Smyrk; James R. Stone; Masayuki Takahira; Hisanori Umehara; George Webster; Motohisa Yamamoto; Eunhee Yi; Tadashi Yoshino; Giuseppe Zamboni; Yoh Zen; Suresh Chari (October 2012). "Recommendations for the nomenclature of IgG4-related disease and its individual organ system manifestations". Arthritis & Rheumatism. 64 (10): 3061–3067. doi:10.1002/art.34593. PMC 5963880. PMID 22736240.
Vikram Deshpande; Yoh Zen; John KC Chan; Eunhee E Yi; Yasuharu Sato; Tadashi Yoshino; Günter Klöppe; J Godfrey Heathcote; Arezou Khosroshahi; Judith A Ferry; Rob C Aalberse; Donald B Bloch; William R Brugge; Adrian C Bateman; Mollie N Carruthers; Suresh T Chari; Wah Cheuk; Lynn D Cornell; Carlos Fernandez-Del Castillo; David G Forcione; Daniel L Hamilos; Terumi Kamisawa; Satomi Kasashima; Shigeyuki Kawa; Mitsuhiro Kawano; Gregory Y Lauwers; Yasufumi Masaki; Yasuni Nakanuma; Kenji Notohara; Kazuichi Okazaki; Ji Kon Ryu; Takako Saeki; Dushyant V Sahani; Thomas C Smyrk; James R Stone; Masayuki Takahira; George J Webster; Motohisa Yamamoto; Giuseppe Zamboni; Hisanori Umehara; John H Stone (18 May 2012). "Consensus statement on the pathology of IgG4-related disease". Modern Pathology. 25 (9): 1181–1192. doi:10.1038/modpathol.2012.72. PMID 22596100.
Arezou Khosroshahi; Zachary S. Wallace; Jayne Littlejohn Crowe; Takashi Akamizu; Atsushi Azumi; Mollie N. Carruthers; Suresh T. Chari; Emanuel Della-Torre; Luca Frulloni; Hiroshi Goto; Phillip A. Hart; Terumi Kamisawa; Shigeyuki Kawa; Mitsuhiro Kawano; Myung-Hwan Kim; Yuzo Kodama; Kensuke Kubota; Markus M Lerch; Matthias Löhr; Yasufumi Masaki; Shoko Matsui; Tsuneyo Mimori; Seiji Nakamura; Takahiro Nakazawa; Hirotaka Ohara; Kazuichi Okazaki; Jay H. Ryu; Takako Saeki; Nicolas Schleinitz; Akira Shimatsu; Tooru Shimosegawa; Hiroki Takahashi; Masayuki Takahira; Atsushi Tanaka; Mark Topazian; Hisanori Umehara; George J. Webster; Thomas E. Witzig; Motohisa Yamamoto; Wen Zhang; Tsutomu Chiba; John H. Stone (July 2015). "International Consensus Guidance Statement on the Management and Treatment of IgG4-Related Disease". Arthritis & Rheumatology. 67 (7): 1688–1699. doi:10.1002/art.39132. PMID 25809420.
Terumi Kamisawa; Yoh Zen; Shiv Pillai; John H. Stone (11 April 2015). "IgG4-related disease". The Lancet. 385 (9976): 1460–1471. doi:10.1016/S0140-6736(14)60720-0. PMID 25481618.
Walsh, Nancy (1 April 2015). "Experts Weigh In on IgG4 Disease - Diagnosis requires biopsy, and treatment starts with steroids". MedPage Today. Retrieved 6 March 2016.
Somalinga Nagendran Karthik; K. Bhanu; Sakthi Velayutham; M. Jawahar (July–September 2011). "Hypertrophic pachymeningitis". Annals of Indian Academy of Neurology. 14 (3): 203–204. doi:10.4103/0972-2327.85896. PMC 3200046. PMID 22028536.
Young-Sub Lee; Hye Won Lee; Ki-Su Park; Seong-Hyun Park; Jeong-Hyun Hwang (October 2014). "Immunoglobulin G4-Related Hypertrophic Pachymeningitis with Skull Involvement". Brain Tumor Research and Treatment. 2 (2): 87–91. doi:10.14791/btrt.2014.2.2.87. PMC 4231624. PMID 25408931.
Jesica Romina Gallo; Alberto Christian Ortiz; Sergio Oscar Paira (September 2014). "IgG4-Related Disease and Sensorineural Hearing Loss". Clinical and Experimental Otorhinolaryngology. 7 (3): 236–237. doi:10.3342/ceo.2014.7.3.236. PMC 4135164. PMID 25177444.
Akira Shimatsu; Yutaka Oki; Ichiro Fujisawa; Toshiaki Sano (December 2009). "Pituitary and stalk lesions (infundibulo-hypophysitis) associated with immunoglobulin G4-related systemic disease: an emerging clinical entity". Endocrine Journal. 56 (9): 1033–1041. doi:10.1507/endocrj.K09E-277. PMID 19926920.
Takahira, Masayuki; Azumi, Atsushi (21 November 2013). "Chapter 12: Ophthalmology". In Hisanori Umehara; Kazuichi Okazaki; John H. Stone; Shigeyuki Kawa; Mitsuhiro Kawano. IgG4-Related Disease. Springer Science & Business Media. pp. 77–84. doi:10.1007/978-4-431-54228-5. ISBN 978-4-431-54227-8.
Jiwon Seo; In Ji Song; Sak Lee; Hyeon Joo Jeong; Hye Min Kim; Beom Seok Koh; Sung Ha Park (March 2015). "A Case of Constrictive Pericarditis due to Immunoglobulin G4-Related Disease". Korean Circulation Journal. 45 (2): 161–164. doi:10.4070/kcj.2015.45.2.161. PMC 4372983. PMID 25810739.
Changho Song; Myoung Ju Koh; Yong-Nam Yoon; Boyoung Joung; Se Hoon Kim (1 September 2013). "IgG4-related sclerosing disease involving the superior vena cava and the atrial septum of the heart". Yonsei Medical Journal. 54 (5): 1285–1288. doi:10.3349/ymj.2013.54.5.1285. PMC 3743176. PMID 23918583.
Qi Qian; Kianoush B. Kashani; Dylan V. Miller (10 September 2009). "Ruptured abdominal aortic aneurysm related to IgG4 periaortitis". The New England Journal of Medicine. 361 (11): 1121–1123. doi:10.1056/NEJMc0905265. PMID 19741239.
Satomi Kasashima; Yoh Zen (26 January 2011). "IgG4-related Inflammatory Abdominal Aortic Aneurysm, Spectrum of IgG4-related Chronic Periaortitis". Annals of Vascular Diseases. 3 (3): 182–189. doi:10.3400/avd.sasvp01002. PMC 3595781. PMID 23555408.
John H. Stone; Arezou Khosroshahi; Alan Hilgenberg; Amy Spooner; Eric M. Isselbacher; James R. Stone (October 2009). "IgG4-related systemic disease and lymphoplasmacytic aortitis". Arthritis & Rheumatism. 60 (10): 3139–3145. doi:10.1002/art.24798. PMID 19790067.
Andrea Barp; Marny Fedrigo; Filippo Maria Farina; Sandro Lepidi; Francesco Causin; Chiara Castellani; Giacomo Cester; Thiene; Marialuisa Valente; Claudio Baracchini; Annalisa Angelini (January–February 2016). "Carotid aneurism with acute dissection: an unusual case of IgG4-related diseases". Cardiovascular Pathology. 25 (1): 59–62. doi:10.1016/j.carpath.2015.08.006. PMID 26453089.
Inoue, Dai; Yoshida, Kotaro; Yoneda, Norihide; Ozaki, Kumi; Matsubara, Takashi; Nagai, Keiichi; Okumura, Kenichirou; Toshima, Fumihito; Toyama, Jun (April 2015). "IgG4-Related Disease: Dataset of 235 Consecutive Patients". Medicine. 94 (15): e680. doi:10.1097/MD.0000000000000680. PMC 4602507. PMID 25881845.
Guillermo Delgado-García; Sergio Sánchez-Salazar; Erick Rendón-Ramírez; Mario Castro-Medina; Bárbara Sáenz-Ibarra; álvaro Barboza-Quintana; María Azalea Loredo-Alanis; David Hernández-Barajas; Dionicio Galarza-Delgado (November 2016). "Myocardial ischemia as presenting manifestation of IgG4-related disease: a case-based review". Clinical Rheumatology. 35 (11): 2857–2864. doi:10.1007/s10067-016-3292-z. PMID 27142374.
Paulo Sampaio Gutierrez; Thiago Schultz; Sheila Aparecida Coelho Siqueira; Luciano de Figueiredo Borges (November–December 2013). "Sudden coronary death due to IgG4-related disease". Cardiovascular Pathology. 22 (6): 505–507. doi:10.1016/j.carpath.2013.05.003. PMID 23830124.
Brittany J. Holmes; Nikolay G. Delev; Gary R. Pasternack; Marc K. Halushka (12 June 2012). "Novel cause of sudden cardiac death: IgG4-related disease". Circulation. 125 (23): 2956–2957. doi:10.1161/CIRCULATIONAHA.111.061002. PMID 22689933.
Edward M. Kobraei; Tae H. Song; Douglas J. Mathisen; Vikram Deshpande; Eugene J. Mark (October 2013). "Immunoglobulin G4-Related Disease Presenting as an Obstructing Tracheal Mass: Consideration of Surgical Indications". The Annals of Thoracic Surgery. 96 (4): e91–e93. doi:10.1016/j.athoracsur.2013.04.120. PMID 24088500.
Hirotsugu Ohkubo; Mikinori Miyazaki; Tetsuya Oguri; Atsushi Arakawa; Yoichiro Kobashi; Akio Niimi (June 2015). "A rare case of IgG4-related disease involving the uterus". Rheumatology. 54 (6): 1124–1125. doi:10.1093/rheumatology/kev024. PMID 25810424.
Jong Hyun Choi; Jae Kyeom Sim; Jee Youn Oh; Eun Joo Lee; Gyu Young Hur; Seung Heon Lee; Sung Yong Lee; Je Hyeong Kim; Sang Yeub Lee; Chol Shin; Jae Jeong Shim; Kwang Ho In; Kyung Ho Kang; Kyung Hoon Min (April 2014). "A Case of IgG4-Related Disease Presenting as Massive Pleural Effusion and Thrombophlebitis". Tuberculosis and Respiratory Diseases. 76 (4): 179–183. doi:10.4046/trd.2014.76.4.179. PMC 4021266. PMID 24851132.
Hyuk Lee; Mee Joo; Tae Jun Song; Sun Hee Chang; Hanseong Kim; Yeon Soo Kim; Ji Yoon Ryoo (April 2011). "IgG4-related sclerosing esophagitis: a case report". Gastrointestinal Endoscopy. 73 (4): 834–837. doi:10.1016/j.gie.2010.08.043. PMID 21067736.
Myriam Dumas-Campagna; Simon Bouchard; Genevieve Soucy; Mickael Bouina (August 2014). "IgG4-related esophageal disease presenting as esophagitis dissecans superficialis with chronic strictures". Journal of Clinical Medicine Research. 6 (4): 295–298. doi:10.14740/jocmr1845w. PMC 4039102. PMID 24883156.
Bruno Coulier; Luc Montfort; Gabriela Beniuga; Frederic Pierard; Isabelle Gielen (January–February 2014). "Small Bowel Obstruction Caused by Peritoneal Immunoglobulin G4-Related Disease Mimicking Carcinomatosis: Case Report". Korean Journal of Radiology. 15 (1): 66–71. doi:10.3348/kjr.2014.15.1.66. PMC 3909864. PMID 24497794.
Yassaman Raissian; Samih H. Nasr; Christopher P. Larsen; Robert B. Colvin; Thomas C. Smyrk; Naoki Takahashi; Ami Bhalodia; Aliyah R. Sohani; Lizhi Zhang; Suresh Chari; Sanjeev Sethi; Mary E. Fidler; Lynn D. Cornell (July 2011). "Diagnosis of IgG4-Related Tubulointerstitial Nephritis". Journal of the American Society of Nephrology. 22 (7): 1343–1352. doi:10.1681/ASN.2011010062. PMC 3137582. PMID 21719792.
Satoshi Yazawa; Rei Ohara; Takahiro Maeda; Kent Kanao; Seiya Hattori; Yosuke Nakajima; Mototsugu Oya (July 2013). "". Nihon Hinyokika Gakkai Zasshi (The Japanese Journal of Urology) (in Japanese). 104 (4): 620–625. doi:10.5980/jpnjurol.104.620. PMID 23971373.
Bobby B Najari; Brian D Robinson; Stephen A Paget; Darius A Paduch (October 2014). "Clinical, radiographic, and pathologic description of IgG4-related perivasal fibrosis: a previously undescribed etiology of chronic orchialgia". Urology. 84 (4): 748–750. doi:10.1016/j.urology.2014.06.035. PMID 25260440.
Arezou Khosroshahi; John H. Stone (January 2011). "A clinical overview of IgG4-related systemic disease". Current Opinion in Rheumatology. 23 (1): 57–66. doi:10.1097/BOR.0b013e3283418057. PMID 21124086.
John H. Stone; Yoh Zen; Vikram Deshpande (February 2012). "IgG4-Related Disease". The New England Journal of Medicine. 366 (6): 539–51. doi:10.1056/NEJMra1104650. PMID 22316447.
Herwig Pieringer; Ilse Parzer; Adelheid Wöhrer; Petra Reis; Bastian Oppl; Jochen Zwerina (16 July 2014). "IgG4- related disease: an orphan disease with many faces". Orphanet Journal of Rare Diseases. 9: 110. doi:10.1186/s13023-014-0110-z. PMC 4223520. PMID 25026959.
Tetsuo Himi; Kenichi Takano; Motohisa Yamamoto; Yasuyoshi Naishiro; Hiroki Takahashi (February 2012). "A novel concept of Mikulicz's disease as IgG4-related disease". Auris Nasus Larynx. 39 (1): 9–17. doi:10.1016/j.anl.2011.01.023. PMID 21571468.
Yueyang Guo; David Ansdell; Sharon Brouha; Andrew Yen (January 2015). "Coronary periarteritis in a patient with multi-organ IgG4-related disease". Journal of Radiology Case Reports. 9 (1): 1–17. doi:10.3941/jrcr.v9i1.1967. PMC 4391803. PMID 25926916.
Vikram Deshpande; Arezou Khosroshahi; Gunnlaugur P Nielsen; Daniel L Hamilos; John H Stone (May 2011). "Eosinophilic angiocentric fibrosis is a form of IgG4-related systemic disease". The American Journal of Surgical Pathology. 35 (5): 701–706. doi:10.1097/PAS.0b013e318213889e. PMID 21502911.
Mollie N. Carruthers; Eli M. Miloslavsk; John H. Stone (August 2013). "Reply to "IgG4-related pharyngitis-an addition to the nomenclature of IgG4-related disease: comment on the article by Stone et al."". Arthritis & Rheumatism. 65 (8): 2217–2218. doi:10.1002/art.37998. PMID 23677887.
Wah Cheuk; Fiona K Y Tam; Alice N H Chan; Ivy S C Luk; Anthony P W Yuen; Wai-Kong Chan; Terry C W Hung; John K C Chan (November 2010). "Idiopathic cervical fibrosis--a new member of IgG4-related sclerosing diseases: report of 4 cases, 1 complicated by composite lymphoma". The American Journal of Surgical Pathology. 34 (11): 1678–1685. doi:10.1097/PAS.0b013e3181f12c85. PMID 20871392.
Shyamal H. Mehta; Jeffrey A. Switzer; Paul Biddinger; Amyn M. Rojiani (11 February 2014). "IgG4-related leptomeningitis: a reversible cause of rapidly progressive cognitive decline". Neurology. 82 (6): 540–542. doi:10.1212/WNL.0000000000000100. PMID 24384648.
Akiyuki Hiraga; Daisuke Ozaki; Atsuko Tsuneyama; Seiro Ito; Kyosuke Koide; Satoshi Kuwabara (15 October 2015). "Corticosteroid-responsive leptomeningitis with IgG4-positive plasma-cell infiltration". Journal of the Neurological Sciences. 357 (1–2): 338–340. doi:10.1016/j.jns.2015.07.048. PMID 26254623.
Terumi Kamisawa; Yuyang Tu; Naoto Egawa; Nobuhiro Sakaki; Jun-ichi Ishiwata; Kouji Tsuruta; Atsutake Okamoto; Toshio Takahashi; Morio Koike (January 2001). "". Nippon Shokakibyo Gakkai Zasshi (The Japanese Journal of Gastroenterology) (in Japanese). 98 (1): 15–24. doi:10.11405/nisshoshi1964.98.15. PMID 11201120.
Dai Inoue; Yoh Zen; Hitoshi Abo; Toshifumi Gabata; Hiroshi Demachi; Jyun Yoshikawa; Shiro Miyayama; Yasuni Nakanuma; Osamu Matsui (November 2011). "Immunoglobulin G4–related Periaortitis and Periarteritis: CT Findings in 17 Patients". Radiology. 261 (2): 625–633. doi:10.1148/radiol.11102250. PMID 21803920.
Verghese George; Varaha Sairam Tammisetti; Venkateswar Rao Surabhi; Alampady K. Shanbhogue (July 2013). "Chronic Fibrosing Conditions in Abdominal Imaging". RadioGraphics. 33 (4): 1053–1080. doi:10.1148/rg.334125081. PMID 23842972.
Jin Hee Kim; Jae Ho Byun; Seung Soo Lee; Hyoung Jung Kim; Moon-Gyu Lee (January 2013). "Atypical Manifestations of IgG4-Related Sclerosing Disease in the Abdomen: Imaging Findings and Pathologic Correlations". American Journal of Roentgenology. 200 (1): 102–111. doi:10.2214/AJR.12.8783. PMID 23255748.
Takashi Karashima; Yoshinori Taniguchi; Tsutomu Shimamoto; Tomoya Nao; Hiroshi Nishikawa; Satoshi Fukata; Masayuki Kamada; Keiji Inoue; Kentaro Oko; Hideki Nakajima; Shigetoshi Sano; Manabu Matsumoto; Naoto Kuroda; Yoshihiro Kamei; Taro Shuin (9 December 2014). "IgG4-related disease of the paratestis in a patient with Wells syndrome: a case report". Diagnostic Pathology. 9: 225. doi:10.1186/s13000-014-0225-5. PMC 4265405. PMID 25487870.
Hans Bösmüller; Claus Hann von Weyhern; Patrick Adam; Vedat Alibegovic; Gregor Mikuz; Falko Fend (January 2011). "Paratesticular fibrous pseudotumor--an IgG4-related disorder?". Virchows Archiv: the European Journal of Pathology. 458 (1): 109–113. doi:10.1007/s00428-010-0995-4. PMID 20957491.
Yasuhito Hamaguchi; Manabu Fujimoto; Yukiyo Matsushita; Seiko Kitamura-Sawada; Mitsuhiro Kawano; Kazuhiko Takehara (2011). "IgG4-related skin disease, a mimic of angiolymphoid hyperplasia with eosinophilia". Dermatology. 223 (4): 301–305. doi:10.1159/000335372. PMID 22269779.
Yoshiki Tokura; Hiroaki Yagi; H. Yanaguchi; Yuta Majima; Akira Kasuya; Taisuke Ito; M Maekawa; Hideo Hashizume (November 2014). "IgG4-related skin disease". British Journal of Dermatology. 171 (5): 959–967. doi:10.1111/bjd.13296. PMID 25065694.
Dai Inoue; Yoh Zen; Yasuharu Sato; Hitoshi Abo; Hiroshi Demachi; Akio Uchiyama; Toshifumi Gabata; Osamu Matsui (2012). "IgG4-Related Perineural Disease". International Journal of Rheumatology. 2012: 1–9. doi:10.1155/2012/401890. PMC 3317227. PMID 22523496.
Nicholas Andrew; Daniel Kearney; Nicole Sladden; Alastair Goss; Dinesh Selva (April 2014). "Immunoglobulin G4-related disease of the hard palate". Journal of Oral and Maxillofacial Surgery. 72 (4): 717–723. doi:10.1016/j.joms.2013.08.033. PMID 24268962.
Katie E. Rollins; Samir P. Mehta; Maria O'Donovan; Peter M. Safranek (2011). "Gastric IgG4-Related Autoimmune Fibrosclerosing Pseudotumour: A Novel Location". ISRN Gastroenterology. 2011 (2011): 873087. doi:10.5402/2011/873087. PMC 3168566. PMID 21991533.
Younghwan Ko; Ji Young Woo; Jeong Won Kim; Hye Sook Hong; Ik Yang; Yul Lee; Daehyun Hwang; Seon Jeong Min (Sep–Oct 2013). "An Immunoglobulin G4-Related Sclerosing Disease of the Small Bowel: CT and Small Bowel Series Findings". Korean Journal of Radiology. 14 (5): 776–780. doi:10.3348/kjr.2013.14.5.776. PMC 3772257. PMID 24043971.
Sung-Bong Choi; Chul-Hyun Lim; Myung-Guen Cha; Won-Kyung Kang (2 May 2016). "IgG4-related disease of the rectum". Annals of Surgical Treatment and Research. 90 (5): 292–295. doi:10.4174/astr.2016.90.5.292. PMC 4865708. PMID 27186575.
C. Costa; C. Saraiva; S. Freitas (25 September 2013). "Adrenal lesion as first manifestation of IgG4-related sclerosing disease". EuroRad. European Society of Radiology. doi:10.1594/EURORAD/CASE.11230. Retrieved 15 May 2015.
Miroslav Sekulic; Simona Pichler Sekulic; Saeid Movahedi-Lankarani (4 May 2016). "IgG4-related Disease of the Ovary: A First Description". International Journal of Gynecological Pathology. 36 (2): 190–194. doi:10.1097/PGP.0000000000000293. PMID 27149005.
Sun A. Kim; Sang-Ryung Lee; Jooryung Huh; Steven S. Shen; Jae Y. Ro (August 2011). "IgG4-associated inflammatory pseudotumor of ureter: clinicopathologic and immunohistochemical study of 3 cases". Human Pathology. 42 (8): 1178–1184. doi:10.1016/j.humpath.2010.03.011. PMID 21334715.
Sanghui Park; Jae Y. Ro; Dong Hyeon Lee; Sun Young Choi; Heasoo Koo (December 2013). "Immunoglobulin G4-associated inflammatory pseudotumor of urinary bladder: a case report". Annals of Diagnostic Pathology. 17 (6): 540–543. doi:10.1016/j.anndiagpath.2013.01.004. PMID 23434261.
Travis W. Dum; Da Zhang; Eugene K. Lee (2015). "IgG4-Related Disease in a Urachal Tumor". Case Reports in Urology. 2014 (2015): 275850. doi:10.1155/2014/275850. PMC 4151357. PMID 25202466.
Koichiro Shinoda; Shoko Matsui; Hirofumi Taki; Hiroyuki Hounoki; Reina Ogawa; Shin Ishizawa; Kazuyuki Tobe (January 2011). "Deforming arthropathy in a patient with IgG4-related systemic disease: Comment on the article by Stone et al". Arthritis Care & Research. 63 (1): 172. doi:10.1002/acr.20297. PMID 20662046.
Takao Taniguchi; Hisato Kobayashi; Shouichi Fukui; Keiji Ogura; Tatuyoshi Saiga; Motozumi Okamoto (September 2006). "A case of multifocal fibrosclerosis involving posterior mediastinal fibrosis, retroperitoneal fibrosis, and a left seminal vesicle with elevated serum IgG4". Human Pathology. 37 (9): 1237–1239. doi:10.1016/j.humpath.2006.03.021. PMID 16938531.
Gerhard Seifert; Karl Donath (March 1977). "Zur Pathogenese des Küttner-Tumors der Submandibularis - Analyse von 347 Fällen mit chronischer Sialadenitis der Submandibularis" . HNO (in German). 25 (3): 81–92. PMID 856776.
Zachary S. Wallace; Hamid Mattoo; Vinay S. Mahajan; Maria Kulikova; Leo Lu1; Vikram Deshpande; Hyon K. Choi; Shiv Pillai; John H. Stone (6 June 2016). "Predictors of disease relapse in IgG4-related disease following rituximab". Rheumatology. 55 (6): 1000–1008. doi:10.1093/rheumatology/kev438. PMC 4900135. PMID 26888853.
Cory A. Perugino; John H. Stone (September 2016). "Treatment of IgG4-related disease: Current and future approaches". Zeitschrift für Rheumatologie. 75 (7): 681–686. doi:10.1007/s00393-016-0142-y. PMC 5953192. PMID 27431746.
"Xencor Initiates Two Phase 2 Trials of XmAb5871 in IgG4-Related Disease and Systemic Lupus Erythematosus". PR Newswire. 7 March 2016. Retrieved 23 July 2016. The primary objective of the study is to evaluate the effect of every other week IV administration of XmAb5871 on the IgG4-RD Responder Index (RI) in patients with active IgG4-RD.
"Final Results of an Open Label Phase 2 Study of a Reversible B Cell Inhibitor, Xmab®5871, in IgG4-Related Disease - ACR Meeting Abstracts". ACR Meeting Abstracts.
Hisanori Umehara; Kazuichi Okazaki; Yasufumi Masaki; Mitsuhiro Kawano; Motohisa Yamamoto; Takako Saeki; Shoko Matsui; Takayuki Sumida; Tsuneyo Mimori; Yoshiya Tanaka; Kazuo Tsubota; Tadashi Yoshino; Shigeyuki Kawa; Ritsuro Suzuki; Tsutomu Takegami; Naohisa Tomosugi; Nozomu Kurose; Yasuhito Ishigaki; Atsushi Azumi; Masaru Kojima; Shigeo Nakamura; Dai Inoue; The Research Program for Intractable Disease by Ministry of Health, Labor and Welfare Japan G4 team (February 2012). "A novel clinical entity, IgG4-related disease (IgG4RD): general concept and details". Modern Rheumatology. 22 (1): 1–14. doi:10.1007/s10165-011-0508-6. PMC 3278618. PMID 21881964.
"Clinical Commissioning Policy: Rituximab for immunoglobulin G4-related disease (IgG4-RD)" (PDF). NHS England. December 2016. Retrieved 27 January 2017.
页:
[1]