Advances in research on mechanism of bacterial resistance to disinfectants 李晓青 关键词：消毒剂；细菌抗性；抗菌机理 随着消毒剂广泛使用,尤其是细菌反复接触亚致死量消毒剂,可使细菌对其产生抗性.与耐抗生素菌株一样,抗消毒剂菌株的出现可能将会导致医院消毒的失败.因此,探索细菌对消毒剂产生抗性的机理,以减少抗消毒剂菌株的产生显得十分必要.近年来,人们对细菌抗消毒剂的机理有较多研究,现将有关结果综述如下.…… 作者单位：李晓青（中国预防医学科学院流行病学微生物学研究所北京 100021） 参考文献： ［1］陆德源主编.医学微生物学.北京:人民卫生出版社,1991:9. ［2］Hammond SM, Lambert PA, Rycroft AN. The Bacterial Cell Surface. London: Croom Helm, 1984. ［3］Brozel VS, Cloete TE. Resistance of Pseudomonas aeruginosa to isothiazolone. J Appl Bacteriol 1994;76:576. ［4］Russell AD. Resistance of Enterobacteriaceae to preservatives and disinfectants. J Appl Bacteriol 1988;Symposium Supplement: 167s. ［5］Nikaido H, Vaara T. Molecular basis of bacterial outer membrane permeability. Microbiol Rev 1985;49:1. ［6］Klemperer RMM, Ishmail NTA. Effects of Rplasmid RP1 and mutrieny depletion on the resistance of Escherichia coli to cetrimide, chlorhexidine and phenol. J Appl Bacterio11980; 48: 349. ［7］Kaulfers PM. Epidemiology and reasons for microbial resistance to biocides. Zentralbl-HgUmweltmed 1995; 197(1-3): 252. ［8］Grenier D, Bertrand J, Mayrand D. Porphytomonas gingivalis outer membrane vesicles promote bacterial resistance to chlorhexidine. Oral Microbiol Immunol 1995;10(15):319. ［9］Howe T G B. Genetic modification of the organism and antibiotic resistance.In Control of Antibiotic-resistant Bacteria ed. Stuart-Harris, C.H.1982. ［10］Hugo WB. Disinfection mechanism. In Russell AD et al ed. Principles and Practice of Disinfection, Preservation and Sterilization 2nd ed. Oxford:Blackwell Scientific Publications, 1992: 199. ［11］Brown MRW. The role of the cell envelope in resistance. In Resistance of Pseudomonas aeruginosa,London: John Wiley and Sons, 1975: 71. ［12］Belliveau BH,Trevors JT. Mercury resistance determined by a self-transmissible plasmid in Bacillus cereus. Biol Met 1990; 3(3-4):188. ［13］Mchugh GL,Hopkins CC.Salmonella typhimurium resistance tosilver nitrate, chlorampheniol and ampicillin. Lancet 1975; 1 :235. ［14］Hendry AT, Stewart LD. Silver-resistant Enterobacteriaceae from hospital patients. Can J Microbo11979; 25: 915. ［15］Morby AP, Hobman JL, Brown NL. The role of cysteine residues in the transport of mervuric ions by the Tn501 MerTand MerP mercury-resistance proteins. Mol Microbio11995; 17(1): 25. ［16］Raymond JT, Diane ET, Joel HW. Expression of Escherichia coli. TehA gives resistance to antiseptics and disinfectants similar to that conferred by multidrug resistance efflux pumps. Antimicrob Agents Chemother 1997; 41 (2):440. ［17］Leelaporn A, Paulsen IT, Tennent JM. Multidrug resistance to antiseptic and disinfectants in coagulase-negative staphylococci. J Med Microbiol 1994; 40(3):214. ［18］Kummerle . N, Feucht HH, Kaulfers PM.Plasmid-Mediated formaldehyde resistance in Escherichia coli. characterization of resistance gene.Antimicrob Agents Chemother 1996; 40 (10): 2276. ［19］Kurihara-T, Sugita M, Motai S,et al. In vitro induction of chlorhexidine and benzalkonium-resistance in clinically isolated Pseudomonas aeruginosa.Kansenshogaku Zasshi 1993; 67(3):202. ［20］Yu H, Chu L, Misra TK. Intracellular inducer Hg2+ concentration is rate determining for the expression of the mercury-resistance operon in cells. J Bacteriol 1996; 178(9):2712. ［21］Nagai I, Ogase H. Absence of role for plasmids in resistance to multiple disinfectants in three strains of bacteria. J Hosp Infect 1990; 15 (2): 149. 更多相关文档请点击>>进展(946)消毒(491)研究(6533)resistance(2)to(34)and(1076) |
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