Two kinds of newly discovered hepatitis virus and present status of their epidemiological research 杜兰英 何军 王海涛 庄辉 关键词：肝炎病毒HGVTTV 分类号：R472 文献标识码：B 1989年以前，人们以“非甲非乙型肝炎”表示那些未知病原所致的肝炎。丙型肝炎病毒(HCV)的发现打破了这种僵局，但发现它是肠道外非甲非乙型肝炎的主要病原〔1〕。后来，Reyes等成功地分离出戊型肝炎病毒(HEV)，而它则是经肠道传播非甲非乙型肝炎的主要病原〔2〕。1994年，Deka等〔3〕用一名患有散发性非甲非乙型肝炎的法国病人粪便接种猕猴，在猕猴体内找到一种直径为27～32 nm的病毒颗粒，其基因组长约20kb，过早乐观地将其命名为HFV，后因该项研究未能重复进行而难以为人们接受。另外一些病毒，如EBV、CMV、HSV等，在某些特定条件下亦能导致肝炎发生，但此种情况极少见。尽管如此，仍有20％的急性肝炎，3％～9％的肝硬化，30％～50％的暴发性肝炎找不到可解释的原因。…… 作者单位：杜兰英（北京大学基础医学院微生物学系，北京 100083） 何军（北京大学基础医学院微生物学系，北京 100083） 王海涛（北京大学基础医学院微生物学系，北京 100083） 庄辉（北京大学基础医学院微生物学系，北京 100083） 参考文献： ［1］Choo QL, Kuo G, Weiner AJ. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science, 1989; 244(4902):359. ［2］Reyes GR, Huang CC, Yarbough PO, et al.Hepatitis E virus. Comparison of New and Old World′ isolates. J Hepatol, 1991 ;13 (Suppl 4):S155. ［3］Deka N, Shama MD, Mukerlee R. Isolation of the novel agent from human stool samples that is associated with sporadic non-A, non-B hepatitis. J Virol,1994; Dec: 7810. ［4］Simons JN, Leary TP, Dawson GJ, et al Isolation of novel virus-like sequence associated with human hepatitis. Nature Medicine, 1995; 1:564. ［5］Linnen J, Jr Wages J, Zhang-Keck ZY, et al. Molecular clobning and disease association of hepatitis G virus: A transfusion -transmissible agent. Science,1996; 271: 505. ［6］Nishizawa T, Okamoto H. A novel DNA virus (TTV) associated with elevated transaminase levels in posttransfusion hepatitis of unknown etiology.Biochem Biophys Res Commun, 1997; 241 (1): 92. ［7］Viazov S, Riffelmann M, Khoudyakov Y, et al. Genetic heterogeneity of hepatitis G virus isolates from different parts of the world. J Gen Virol, 1997;78 (Pt 3):577. ［8］Thomas HC, Pickering J, Karayiannis P, et al. Identification, prevalence and aspects of molecular biolo-gy of hepatitis G virus. J Viral Hepat, 1997; 4 (1):51. ［9］Okamoto H, Nakao H, Inoue T, et al The entire nucleotide sequences of two GBV-C / hepatitis G virus isolates of distict genotypes from Japan. J Gen Virol, 1997; 78 pt4: 737. ［10］Nakao H, Okamoto H, Fukuda M, et al. Mutation rate of GB virus-C / hepatitis G virus over the entire genome and in subgenomic regions. Virology,1997; 233(1): 43. ［11］Wang xingtai , Zhuang Hui, Li Hemin, et al.Macaca Mulatta as Animal Model of HGV Infection. Chin J Microbiol Immunol, 1997; 17(5): 363. ［12］Ikeda M, Sugiyama K, Mizutani T. Hepatitis G virus replication in human cultured cells displaying susceptibility to hepatitis C virus infection.Biochem Biophys Res Commun, 1997; 235(3): 505. ［13］周育森,陈薇,赵慧柳,等.中国庚型肝炎病毒(HGV)全基因结构特点及HGV感染的地理分布.微生物学通报,1997；1：27. ［14］Mushahwar IK, Erker JC. Molecular and biophysical characterization of TT virus: Evidence for a new virus family infecting humans. Proc Natl Acad Sci USA, 1999; 96(6): 3177. ［15］周育森,董京芳,何忠平,等.一株TTV中国分离株全基因的克隆及序列测定.中华医学杂志,2000；80(1)：12. ［16］Okamoto H, Nishizawa T, Kayto N, et al. Molecular cloning and characterization of a novel DNA virus ( TTV ) associated with posttransfusion hepatitis of unkown etiology. Hepatol Res, 1997; 10: 1. ［17］周育森,董京芳.我国部分地区几种人群中TTV感染的分子流行病学研究。中华预防医学杂志,1998；32(6)：352. ［18］Okamoto H , Akahane Y. Fecal excretion of a nonenveloped DNA virus ( TTV ) associated with posttransfusion non-A-G hepatitis. J Med Virol,1998; 56(2): 128. ［19］何忠平,周育森,王海涛,等.聚合酶链反应斑点杂交法检测TT病毒感染。中华医学检验杂志,1999；22(3)：142. ［20］Andonov A, Sauder C, Jacobsen H, et al. Comparison of six sets of PCR primers from two different genomic regions for amplification of GB virus C/hepatitis G virus RNA. J Clin Microbiol. 1998;36: 286. 更多相关文档请点击>>病毒(1312)研究(6533)hepatitis(2)virus(4)发现(282)及其(1567) |
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