蝙蝠冠状病毒HKU4（Bat-CoV HKU4）是一种有包膜的，单链RNA哺乳动物2型β冠状病毒，已发现与负责中东呼吸综合征的冠状病毒（MERS-CoV）是导致2012年中东沙特阿拉伯，约旦，阿拉伯联合酋长国，英国，法国和意大利爆发与呼吸道综合症相关的冠状病毒的原因。[1] [2] [3] [4]
内容
1 传播
2 参考
传播
向人类传播的确切方法尚不清楚。 但是，已经证明包括HKU4在内的βCoV具有重组的倾向并引起种间传播。 但是，这在MERS-CoV与之最相关的C组βCov中看不到。[5]
参考文献
Woo, Patrick CY; Lau, Susanna KP; Li, Kenneth SM; Tsang, Alan KL; Yuen, Kwok-Yung (2012). "Genetic relatedness of the novel human group C βcoronavirus to Tylonycteris bat coronavirus HKU4 and Pipistrellus bat coronavirus HKU5". Emerging Microbes & Infections. 1 (11): e35–. doi:10.1038/emi.2012.45. PMC 3630921. PMID 26038405.
Zaki, Ali M.; Van Boheemen, Sander; Bestebroer, Theo M.; Osterhaus, Albert D.M.E.; Fouchier, Ron A.M. (2012). "Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia". New England Journal of Medicine. 367 (19): 1814–20. doi:10.1056/NEJMoa1211721. PMID 23075143.
Woo, Patrick C.Y.; Lau, Susanna K.P.; Li, Kenneth S.M.; Poon, Rosana W.S.; Wong, Beatrice H.L.; Tsoi, Hoi-wah; Yip, Bethanie C.K.; Huang, Yi; Chan, Kwok-Hung; Yuen, Kwok-Yung (2006). "Molecular diversity of coronaviruses in bats". Virology. 351 (1): 180–7. doi:10.1016/j.virol.2006.02.041. PMID 16647731.
Lau, S. K. P.; Li, K. S. M.; Tsang, A. K. L.; Lam, C. S. F.; Ahmed, S.; Chen, H.; Chan, K.-H.; Woo, P. C. Y.; Yuen, K.-Y. (2013). "Genetic Characterization of βcoronavirus Lineage C Viruses in Bats Reveals Marked Sequence Divergence in the Spike Protein of Pipistrellus Bat Coronavirus HKU5 in Japanese Pipistrelle: Implications for the Origin of the Novel Middle East Respiratory Syndrome Coronavirus". Journal of Virology. 87 (15): 8638–50. doi:10.1128/JVI.01055-13. PMC 3719811. PMID 23720729.
Woo, Patrick C. Y.; Huang, Yi; Lau, Susanna K. P.; Yuen, Kwok-Yung (2010). "Coronavirus Genomics and Bioinformatics Analysis". Viruses. 2 (8): 1804–20. doi:10.3390/v2081803. PMC 3185738. PMID 21994708. |
