促性腺激素过多性腺功能亢进是一种内分泌情况，是促性腺激素水平和性腺功能等性腺功能异常高的性腺功能亢进症的一种亚型。 它可能与雄激素过多症和雌激素过多症以及性腺囊肿和肿瘤有关。 它可能是由诸如促性腺激素，促性腺激素释放激素激动剂，非甾体类抗雄激素和选择性雌激素受体调节剂之类的药物引起的，也可能是由人类绒毛膜促性腺激素分泌性肿瘤，完全雄激素不敏感综合征和雌激素不敏感综合征等疾病引起的。
参考
Andrew N. Margioris; George P. Chrousos (20 April 2001). Adrenal Disorders. Springer Science & Business Media. pp. 298–. ISBN 978-1-59259-101-5.
K. Lissak (6 December 2012). Hormones and Brain Function. Springer Science & Business Media. pp. 48–. ISBN 978-1-4684-2007-4.
E.E. Müller (6 December 2012). Peptides and Non Peptides of Oncologic and Neuroendocrine Relevance: From Basic to Clinical Research. Springer Science & Business Media. pp. 231–. ISBN 978-88-470-2085-6. Pure anti-androgens can be given as monotherapy in the attempt to avoid the side effects caused by androgen-suppressive therapies (loss of libido, impotency, osteoporosis, pathological fractures, decrease of muscle mass and tone, progressive anaemia, asthenia, and depression) (Tyrrell, 1992). The use of these compounds in patients with intact gonads induces a condition of hypergonadotrophic hypergonadism, which allows high circulating levels of testosterone to be maintained.
Knuth UA, Hano R, Nieschlag E (November 1984). "Effect of flutamide or cyproterone acetate on pituitary and testicular hormones in normal men". J. Clin. Endocrinol. Metab. 59 (5): 963–9. doi:10.1210/jcem-59-5-963. PMID 6237116. Since FLU is devoid of intrinsic hormonal activity, its antiandrogenic property leads to increased serum testosterone (T) levels and elevated gonadotropin values. The effect of this unique endocrine situation, which may be described as "hypergonadotropic hypergonadism."
Knobil and Neill's Physiology of Reproduction. Academic Press. 12 December 2005. pp. 627–. ISBN 978-0-08-053527-2. |
